Preparation of novel phenyl(imino)sulfanones as isomerohydrolase inhibitor for treatment of atrophic form of age-related macular degeneration and Stargardt disease By: Petrukhin, Konstantin; Cioffi, Christopher L.; Wang, Yuhong; Ma, Jian-Xing; Moiseyev, Gennadiy, WO2022266394 A1 2022-12-22.
Novel compounds comprising a new class of transthyretin ligands for treatment of common age-related comorbidities By: Petrukhin, Konstantin; Racz, Boglarka; Varadi, Andras; Cioffi, Christopher L.; Muthuraman, Parthasarathy; Raja, Arun, WO2022173904 A1 2022-08-18.
Bispecific antagonists of retinol-binding protein 4 that stabilize transthyretin tetramers, their preparation, and use in the treatment of common age-related comorbidities, Petrukhin, Konstantin; Racz, Boglarka; Varadi, Andras; Muthuraman, Parthasarathy; Raja, Arun; Cioffi, Christopher L., US20230348415 A1.
ARF6 inhibitors and methods of synthesis and use thereof, Ostanin, K.; Shenderovich, M.; Bajji, A.; Cioffi, C.; Moss, N.; Vankayalapati, H.; Li, D. US20170189405 A1, US 10849901 B2.
Preparation of substituted 4-phenylpiperidines for treating disease characterized by excessive lipofuscin accumulation in the retina, Petrukhin, K.; Cioffi, C.; Johnson, G.; Allikmets, R.; Dobri, N.; Freeman, E.; Conlon, M.; Chen, P.; Zhu, L. US20150315197 A1, US9434727 B2.
RBP4 antagonists for the treatment of age-related macular degeneration and Stargardt disease, Petrukhin, K.; Cioffi, C.; Johnson, G.; Allikmets, R.; Dobri, N.; Freeman, E.; Conlon, M.; Chen, P.; Zhu, L. US20160030422, US20170258786.
Preparation of 4-phenylpiperidines as RBP4 antagonists, Petrukhin, K.; Cioffi, C.; Johnson, G.; Allikmets, R.; Dobri, N.; Freeman, E.; Conlon, M.; Chen, P.; Zhu, L. US20160046648 A1, US10273243 B2, US20190031681 A1, US11028098 B2, US20210363155 A1, US11919913 B2.
Preparation of octahydrocyclopentapyrroles for the treatment of diseases characterized by excessive lipofuscin accumulation in the retina, Petrukhin, K.; Cioffi, C.; Johnson, G.; Allikmets, R.; Cywin, C.; Dobri, N.; Freeman, E.; Conlon, M.; Chen, P.; Zhu, L. US20160024007 A1, US9637450 B2, US20170247327 A1, US9926271 B2, US20180237391 A1, US10421720 B2.
Preparation of octahydropyrrolopyrroles and -cyclopentapyrroles useful in the treatment of macular degeneration, Petrukhin, K.; Cioffi, C.; Johnson, G.; Allikmets, R.; Cywin, C.; Dobri, N.; Freeman, E.; Conlon, M.; Chen, P.; Zhu, L. US20160046632 A1, US9944644 B2, US20180298012 A1, US10787453 B2.
Preparation of N-alkyl-2-phenoxyethanamines as RBP4 antagonists, Petrukhin, K.; Cioffi, C.; Johnson, G.; Allikmets, R.; Dobri, N.; Freeman, E.; Conlon, M.; Chen, P.; Zhu, L. US20160046649 A1, US9938291 B2, US20180222919 A1, US10570148 B2.
Preparation of substituted 4-phenylpiperidines for treating diseases characterized by excessive lipofuscin accumulation, Petrukhin, K.; Cioffi, C.; Johnson, G.; Allikmets, R.; Dobri, N.; Freeman, E.; Conlon, M.; Chen, P.; Zhu, L. US Patent No. 10407433 B2.
Preparation of pyrrolo[4,3,2-de]isoquinoline and pyrazolo[3,4,5-de]isoquinoline compounds as 5- HT3 receptor modulators for disease treatment, US20090298809 A1, US20120219641 A1,US20130310366 A1, US8710047 B2, US8501729 B2, US8124600 B2.
N-[(Sulfonylpiperazinyl)cycloalkyl]methyl carboxamide derivatives as glycine transporter-1 inhibitors and their preparation, Cioffi, C., Wolf, M.; Guzzo, P.; Sadalapure, K., US20110312931 A1, US9045445 B2.
Synthesis of 2-aminobenzoxazole compounds starting from 2-aminophenols and amines, Cioffi, C., US20100113772 A1, US8178666 B2.
Preparation of benzazepines as inhibitors of cholesterol ester transfer protein for treating dyslipidemia, Cao, G.; A.; Escribano, A.; Fernandez, M-C.; Fields, T.; Gernert, D.; Cioffi, C.; Herr, R.; Mantlo, N.; Martin de la Nava, E-M.; Mateo-Herranz, A.; Mayhugh, D.; Wang, X. US20070254869 A1, US7749992 B2.
Preparation of ben[b]azepines and related compounds as inhibitors of cholesterol ester transfer protein for treating dyslipidemia, Chen, X.; Dinn, S.; Cioffi, C.; Escribano, Fernandez, M-C.; Carmen, M.; Fields, T.; Herr, R.; Mantlo, N.; Martin de la Nava, E-M.; Isabel, A.; Parthasarathy, S.; Wang, X. US20070244095 A1, US20080269284 A1, US7786108 B2, US20100204207 A1.